I
want to know where blood comes from.
Biologically, the blood (hematopoietic) system is fantastically intricate.
The complexity of how it's regulated and responds to environmental stresses
is on par with any other tissue or organ. All the parts of the body
work together in a delicately balanced system of life. However, blood
is among a select few parts of the body with additional, symbolic meaning.
It is blood that is seen to carry our passions. It is blood that is
used to identify our descendants (eg. our bloodline). It is blood
that marks those among us with whom we enter into sacred kinships (eg.
blood brothers). Literature contains abundant references to blood as
a vehicle for understanding deeper human significance. As Sitwell said,
"Blood is that fragile scarlet tree we carry with us."
Works like Macbeth, The Blank Page (Karen von Blixen),
and of course Dracula are just a few examples of how human kind
sees blood as something more than cells and plasma pulsing through our
vessels. Blood's metaphorical nature alone is worthy of study.
That
said, blood is clearly more than poetically significant. People
have studied the blood, both healthy and otherwise, for centuries. From
Paracelsus' comments on splenomegally in the 1500's to the famous clotting
disease of the Romanovs in Russia (and other royal households), what
blood does, and how it does it, is of great scientific and medical interest.
My background is in genetics and my particular research tries to understand
what genes are involved in blood cell production, how that happens at
the earliest stages when the first blood cell is made from its non-blood
precursor, and how the entire process goes astray in disease.
I
do this work using human embryonic stem cells (hESC's). The specific
use of hESC's is key to my work for at least two reasons: (1) I am
interested in understanding the pathophysiology of human genetic
diseases of the blood and (2) embryonic stem cells are capable of making
any type of cell in our bodies, but have yet to do it; they are a blank
slate. Adult blood stem cells are eventually made in nature from
a cell like an embryonic stem cell and I want to understand how that
works. The incredible developmental plasticity of embryonic stem cells
makes them perfect platforms for studying how one cell (the fertilized
egg) is able to divide and make all of the hundreds of different types
of cells in our bodies. This is the central question of developmental
biology.
However,
the use of human hESC's for research has renewed a centuries old
debate into what it means to be human and also how far science should
be allowed to go in order to combat human frailty. As such, the consideration
of areas beyond, yet impacting science is of keen interest to me. Ethics,
philosophy, scientific conduct, public policy and education are important
things that I also do my best to study and be engaged with as part of
my research.
·Lensch
MW and Ince TA. The Terminology of Teratocarcinomas and Teratomas, Nat
Biotechnol. 2007 Nov;25(11):1211-12. ·
Agarwal
S, Lensch MW, Daley GQ. Current prospects for the generation of patient-specific
pluripotent cells from adult tissues. Regen Med. 2007 Sep;2(5):743-52. ·Lensch
MW, Schlaeger TM, Zon LI, Daley GQ. Teratoma Formation Assays with Human
Embryonic Stem Cells: A Rationale for One Type of Human-Animal Chimera. Cell
Stem Cell. 2007 September, 2007: 1 (3):253-8. (go
to full text PDF online) ·
Wu
X*, Lensch MW*, Wylie-Sears J, Daley GQ, Bischoff J. Hemogenic
Endothelial Progenitors Cells Isolated from Human Umbilical Cord Blood. Stem
Cells. 2007, 25:2770-6 (*co-first authors). ·Lensch
MW. Recent advances in stem cell biology (Rapid Response), Southern Medical
Journal, 2007. (in press). ·Lensch
MW and West JA. Looking Into the Future of Cell-Based Therapy, Southern
Medical Journal, 2007. (in press). ·Lensch
MW and Daley, GQ. Embryonic Stem Cells Flock Together (News and Views),
Nat Biotechnol. 2007 Jul;25(7):748-750. ·Lensch
MW, Tulpule A, and Zaehres, H. RNA Interference in Human Embryonic Stem
Cells. Human Embryonic Stem Cells: A Practical Handbook, John Wiley &
Sons, Ltd., Sullivan, Eggan, and Cowan, eds. (2007). ·
Schlaeger
TS, Lensch MW, and Taylor PL. Science Aside: The Trajectory of Embryonic
Stem Cell Research in the USA. Drug Discov Today. 2007 Apr;12(7-8):269-71. ·Lensch
MW, Daheron L, and Schlaeger TS. The Pluripotent Stem Cell Niche. Stem
Cell Rev. 2006;2(3):185-202. ·Lensch
MW and Daley GQ. Scientific and Clinical Opportunities for Modeling Blood
Disorders with Embryonic Stem Cells. Blood. 2006 Apr 1;107(7):2605-12.
·
Zaehres
H, Lensch MW, Daheron L, Stewart SA, Itskovitz-Eldor J, Daley GQ. High-efficiency
RNA interference in human embryonic stem cells. Stem Cells. 2005, 23(3):299-305. ·
Dahéron
L, Opitz SL, Zaehres H, Lensch MW, Andrews PW, Itskovitz-Eldor J, Daley
GQ. LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem
cells. Stem Cells. 2004, 22(5):770-8. ·Lensch
MW and Daley GQ. Origins of mammalian hematopoiesis: in vivo paradigms and
in vitro models. Gerald Shatten ed. Curr Top Dev Biol. 2004;60:127-96. ·Lensch
MW, Tischkowitz M, Christianson TA, Reifsteck C, Speckhart SA, O'Dwyer ME,
Jakobs P, Olson SB, LeBeau MM, Mathew CG, Hodgson SV, Larson R, Bagby GC. Acquired
FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
(Plenary Paper). Blood. 2003 Jul 1;102(1):7-16. ·Lensch
MW. Clonal Selection: The Leukemic Process in Fanconi Anemia, Graduate Thesis,
March 15, 2002, Oregon Health & Science University, Portland, Oregon. ·
Fagerlie
S, Lensch MW, Pang Q, Bagby GC. The Fanconi anemia group C gene product:
signaling functions in hematopoietic cells. Exp Hematol 2001 Dec;29(12):1371-81. ·Lensch
MW, Rathbun RK, Olson SB, Jones GR, Bagby GC Jr. Selective pressure as an
essential force in molecular evolution of myeloid leukemic clones: A view from
the Fanconi anemia window. Leukemia 1999 Nov;13(11):1784-9. ·
Pellegrino
JE, Lensch MW, Muenke M, Chance PF. Clinical and molecular analysis in
Joubert syndrome. Am J Med Genet. 1997 Oct 3;72(1):59-62. ·
Graf
WD, Chance PF, Lensch MW, Eng LJ, Lipe HP, Bird TD. Severe vincristine
neuropathy in Charcot-Marie-Tooth disease type 1A. Cancer. 1996 Apr 1;77(7):1356-62. ·
Kiyosawa
H, Lensch MW, Chance PF. Analysis of the CMT1A-REP repeat: mapping crossover
breakpoints in CMT1A and HNPP. Hum Mol Genet. 1995 Dec;4(12):2327-34.
·
Bone
LJ, Dahl N, Lensch MW, Chance PF, Kelly T, Le Guern E, Magi S, Parry
G, Shapiro H, Wang S, Fischbeck KH. New connexin32 mutations associated with
X-linked Charcot-Marie-Tooth disease. Neurology. 1995 Oct;45(10):1863-6.
·
Chance
PF, Lensch MW, Lipe H, Brown RH Sr, Brown RH Jr, Bird TD. Hereditary
neuralgic amyotrophy and hereditary neuropathy with liability to pressure palsies:
two distinct genetic disorders. Neurology. 1994 Dec;44(12):2253-7. ·
Chance
PF, Abbas N, Lensch MW, Pentao L, Roa BB, Patel PI, Lupski JR. Two autosomal
dominant neuropathies result from reciprocal DNA duplication/deletion of a region
on chromosome 17. Hum Mol Genet. 1994 Feb;3(2):223-8. ·
Bergoffen
J, Scherer SS, Wang S, Scott MO, Bone LJ, Paul DL, Chen K, Lensch MW,
Chance PF, Fischbeck KH. Connexin mutations in X-linked Charcot-Marie-Tooth
disease. Science. 1993 Dec 24;262(5142):2039-42. ·
Chance
PF, Alderson MK, Leppig KA, Lensch MW, Matsunami N, Smith B, Swanson
PD, Odelberg SJ, Disteche CM, Bird TD. DNA deletion associated with hereditary
neuropathy with liability to pressure palsies. Cell. 1993 Jan 15;72(1):143-51.
·
Chance
PF, Bird TD, Matsunami N, Lensch MW, Brothman AR, Feldman GM. Trisomy
17p associated with Charcot-Marie-Tooth neuropathy type 1A phenotype: evidence
for gene dosage as a mechanism in CMT1A. Neurology. 1992 Dec;42(12):2295-9. ·
Matsunami
N, Smith B, Ballard L, Lensch MW, Robertson M, Albertsen H, Hanemann
CO, Muller HW, Bird TD, White R, Chance PF. Peripheral myelin protein-22 gene
maps in the duplication in chromosome 17p11.2 associated with Charcot-Marie-Tooth
1A. Nat Genet. 1992 Jun;1(3):176-9. ·
Chance
PF, Matsunami N, Lensch W, Smith B, Bird TD. Analysis of the DNA duplication
17p11.2 in Charcot-Marie-Tooth neuropathy type 1 pedigrees: additional evidence
for a third autosomal CMT1 locus. Neurology. 1992 Oct;42(10):2037-41.
Public
Policy Commentaries:
·
10/30/07
Testimony, "Testimony Regarding the Advancement of the Life
Sciences in the Commonwealth of Massachusetts", SB.4234, Commonwealth of
Massachusetts State House, Joint Committee on Economic Development and Emerging
Technologies. ·
9/19/07
Invited speaker, Spinal Cord Injury Awareness Day, Massachusetts
State House, Boston, Massachusetts. Eric Ruby, M.D., organizer. ·
6/30/07
Co-author, Report to the Office of the Governor and the General
Assembly, Stem Cell Research Advisory Committee, Connecticut Department of Public
Health, regarding Public Act 05-149, An Act Permitting Stem Cell Research and
Banning the Cloning of Human Beings. ·
3/28/07
Panelist, Interstate Collaboration on Stem Cell Research, Legislative
Office Building, Hartford, Connecticut. StemCONN 07. ·
3/27/07
Invited speaker, Media and Legislative Briefing, Old Judiciary
Room, The Capitol, Hartford, Connecticut. StemCONN 07. ·
1/05/07
Co-author, Report to the Office of the Governor and the General
Assembly, Umbilical Cord Blood Ad Hoc Committee, Connecticut Department of Public
Health, regarding Public Act 06-77, An Act Concerning the Establishment of a
Public Umbilical Cord Blood Bank. ·
4/06/06
Testimony, "Comments on Science and Policy in Stem Cell Research",
Congressional Simulation for students, Kennedy School of Government, Harvard
University. ·
4/21/05
Lecture and Panel, Town Hall Meeting on Stem Cell Research, Jamaica
Plain, Massachusetts. State Representative Jeffrey Sanchez, moderator.
·
3/03/05Lecture and Panel, "Being a Young Investigator in a Contentious
Field" at "The Politics and Promise of Stem Cell Research", Howard
Hughes Medical Institute (HHMI) in collaboration with the Center for Strategic
and International Studies (CSIS), Washington, D.C., Leonard Zon, organizer.
·
6/09/04
Research Advocacy/Lobbying, Joint Steering Committee for Public
Policy (ASCB), Capitol Hill Day, Washington, D.C. ·
4/16/04
Lecture, "Stem Cell Research: Origins, State of the Art,
and Future Directions", MIT Senior Congressional Staff Seminar: "Social
and Policy Implications of Advancing Health Science and Technology", Stephen
Ansolabehere, Ph.D. and Robert Weinberg, Ph.D., organizers. Jonathan Gruber,
Ph.D., moderator. ·
6/18/03
Testimony, "Stem Cell Research", State of Utah Legislature,
Democrat Representatives' Caucus. ·
5/01/03
Testimony, "Stem Cell Research", Commonwealth of Massachusetts
State House, joint legislative session on stem cell research.
Lectures/Articles/Other
Media Relating to My Professional Activities:
·
10/10/07
"Embryonic Stem Cells: History, Current Concepts, and Goals", Beth Israel
Deaconess Medical Center, Boston, Massachusetts. ·
10/01/07
"Stem Cell Therapy: Where Are We and Where Are We Going", Combined Pathology
Grand Rounds, Brigham and Women's Hospital, Boston, Massachusetts. ·
9/26/07
Invited speaker, "A Little History and Some Big Questions", Bioethics
Brown Bag Discussion, Massachusetts General Hospital. Laurence Daheron, Ph.D.
organizer. ·
9/19/07
Invited speaker, Spinal Cord Injury Awareness Day, Massachusetts State House,
Boston, Massachusetts. Eric Ruby, M.D., organizer. ·
9/12/07
Magazine Interview, "Crossing the Lines", Discover Magazine, October
2007, Stephen S. Hall, author. ·
9/11/07
"Stem Cells in Research and Clinical Practice", Grand Rounds, Exeter
Hospital, Exeter, New Hampshire. ·
7/26/07
Commentary, "The
New Valley of Death", Nature Network Boston. ·
7/23/07
Commentary, "The
Deval Is In the Details", Xconomy.com. ·
7/18/07
"Stem Cells at the Confluence of Science and Ethics", Wellesley College,
Wellesley, Massachusetts. ·
7/13/07
Speaker and Panelist, "Law, Business, and Policy in Stem Cell Research",
Professional Development Course for Teachers: Stem Cell Science and Technology,
Harvard Stem Cell Institute, Cambridge, Massachusetts.
· 7/12/07
Invited speaker, "Development: It's Not Just for Frogs Anymore", Grey
Thumb Boston, The Boston Metro Area Technobiology Interest Group, Cambridge, Massachusetts.
·
6/27/07
"The Long and the Short of Stem Cells", Harvard Stem Cell Institute
Summer Seminar Series, Harvard University, Cambridge, Massachusetts. ·
6/22/07
Commentary, "Deval
Patrick Needs You", Xconomy.com. ·
6/20/07
Radio Interview, "Bush
Vetoes Stem Cell Research", Free Speech Radio News (Pacifica Radio),
Leigh Ann Caldwell, reporter. ·
6/14/07
Commentary, "The
Curious Origins of the Term 'Stammzelle'", Cell Stem Cell. ·
6/14/07
"The Analysis of Complex Genetic Syndromes Using Disease-Specific Human Embryonic
Stem Cell Lines", Harvard Stem Cell Institute Annual Retreat, Cambridge,
Massachusetts. ·
6/08/07
Invited speaker, "The Science of Stem Cells", at Stem Cells 2010: What
Lies Ahead. Nixon Peabody LLP, Boston, Massachusetts. ·
4/27/07
Invited speaker, "The Promise of Stem Cells: An Educational Evening on Stem
Cell Research", Greater Boroughs Chapter of Hadassah and the Westborough
Area Jewish Community Center, Westborough, Massachusetts. ·
4/26/07
Speaker and Panelist, "10 Unanswered Questions in Stem Cell Research",
Cambridge Science Festival, Radcliffe College, Cambridge, Massachusetts. ·
4/04/07
"The Ethics, Policy, and Law of Stem Cell Research", Speaker and panelist,
Columbia Law School, Columbia University, New York, New York. ·
3/28/07
Panelist, Interstate Collaboration on Stem Cell Research, Legislative Office Building,
Hartford, Connecticut. StemCONN 07. ·
3/27/07
Invited speaker, Media and Legislative Briefing, Old Judiciary Room, The Capitol,
Hartford, Connecticut. StemCONN 07. ·
3/26/07
"Stem Cell Research: More than Science", Invited Speaker. 12th Annual
Symposium on Biotechnology Education. Museum of Science, Boston, Massachusetts. ·
3/14/07
"Stem Cell Public Forum: Religious Perspectives on Stem Cell Research",
Panelist, Harvard Stem Cell Institute and Harvard Divinity School. Philip Clayton,
Ph.D., Moderator. ·
1/22/07
"‘Recycling’ life: UMass Memorial revives cord blood program for
stem cell transplants", Newspaper interview, Telegram & Gazette, Worcester,
MA. Elizabeth Cooney, author. ·
1/11/07
"Stem
Cell Bill Passes House; Veto Looms", News interview, CBS-4 News, Boston. ·
1/09/07
"Less
Controversial Way to Harvest Stem Cells", Live News Interview/Call-In,
ABC News Video, Be Seen, Be Heard. New York. ·
1/08/07
"Scientists Extract Stem Cells from Amniotic Fluid", News interview,
New England Cable News (NECN), Boston. ·
1/08/07
"Report
Shows Amniotic Fluid Yields Stem Cells", News interview, CBS-4 News,
Boston. ·
1/30/07
"ES Cells in the Study of Development" at "Therapeutic Potential
of Stem Cell Research: from Test Tube to Bedside", University of Newcastle,
Newcastle upon Tyne, UK. ·
12/11/06
Stem Cell Public Forum, Moderated Book Discussion with Authors Eve Harold, Christopher
Thomas Scott, and Michael Bellomo, Harvard Stem Cell Institute and Radcliffe Institute
for Advanced Study. M. William Lensch, Moderator. ·
10/12/06
"The Science of Stem Cells", Southern Medical Association Centennial
Meeting, Charlotte, North Carolina. ·
9/18/06
"New Hope for Stem Cells, or Just More Hype?", Invited Commentary, PharmaDD
Magazine. ·
9/01/06
"Stem cell experiment killed embryos, researchers say", Interview, Baltimore
Sun, Dennis O'Brien, author. ·
8/17/06
"Mister Clone", Interview, L'espresso (Italy), Daniela Cipolloni, author. ·
8/16/06
"Anti-Ban Billionaires", Interview, Forbes Magazine, Matthew Herper
and Robert Langreth, authors. ·
8/10/06
"323 years of stem cell research, 37 years of politics", Harvard Stem
Cell Institute Summer Seminar Series, Harvard University, Cambridge, Massachusetts. ·
7/25/06
"Stem
Cell Research Debate", Radio Call-In Interview, Radio Islam (WCEV - Chicago),
Carlie Pierson, Producer. ·
7/21/06
"Veto de George W. Bush: Une grande déception, mais pas une surprise",
Interview, Le Figaro (France), Philippe Berry, author. ·
7/19/06
"The Stem Cell Future", Live News Interview, New England Cable News
(NECN), Jonah Davis, producer. ·
7/19/06
"Ask the Expert", Magazine Interview, Soap Opera Digest, Naomi Rabinowitz,
author. ·
6/21/06
"Philosophy and Ethics in Human Embryo Research", (with Thorsten Schlaeger)
Harvard Stem Cell Institute Summer Seminar Series, Harvard University, Cambridge,
Massachusetts. ·
6/20/06
"Stem Cell Package", Film Interview, Emerson College, Carrie Sheffield,
author. ·
6/11/06
"Scientists Identify Genes That Let Stem Cells Stay Stem Cells", Interview,
Bloomberg, Rob Waters, author. ·
4/06/06
"Comments on Science and Policy in Stem Cell Research", Testimony, Congressional
Simulation for students, Kennedy School of Government, Harvard University. ·
4/05/06
"Compensation for Oocytes: Personal Liberty v. Paternalism", Lecture
and Discussion, Brown Bag Bioethics Discussion, Division of Hematology/Oncology,
Children's Hospital Boston and Harvard Stem Cell Institute. ·
3/24/06
“Introduction
to the Science of Stem Cells”, Guest Faculty, Suffolk University Law
School, Annual Intellectual Property Law Conference, Boston, Massachusetts. ·
3/21/06
"Nuclear Transfer: From Zoology to Medicine", Lecture, Knight Science
Journalism Fellowships/Nieman Foundation Fellowships, Harvard Stem Cell Institute,
Harvard University, and Massachusetts Institute of Technology. ·
3/20/06
"Stem Cells
in the Blood", Essay, International Society for Stem Cell Research, public
education website. ·
3/20/06
"Stem Cell Ethics 101", Lecture, Knight Science Journalism Fellowships/Nieman
Foundation Fellowships, Harvard Stem Cell Institute, Harvard University, and Massachusetts
Institute of Technology. ·
2/20/06
“Conditional Transgene Expression in Human Embryonic Stem Cells”, Duke
University Medical Center, Durham, North Carolina. ·
2/16/06
“What Happens Next with Stem Cells? The Hope, the Hype, and the Politics”,
Panel Discussion, The BioAgenda Institute, Boston Issues Roundtable. David Ewing
Duncan, host and moderator. ·
1/01/06
"Whose life? Stem-cell research poses tough issues for Ohio lawmakers",
Newspaper Interview, The Columbus Dispatch (Ohio), Jim Siegel, author. ·
12/19/05
“Embryonic stem cell research: how, when, and why?”, Lecture, The Cambridge
Saloon Salon at Redline, Center for Naturalism. Cambridge, Massachusetts. ·
10/23/05
"New Research: Americans Torn over Doing Right Thing", Newspaper Interview,
The Patriot Ledger, Quincy, Massachusetts, Sarah Baldauf, author. ·
10/18/05
"New Stem Cell Tactics Preserve Embryos", Newspaper Interview, Harvard
Crimson, Risheng Xu, author. ·
9/30/05
"Embryonic stem cell research: A political and scientific timeline",
Lecture, Intellectual Property Office, Children's Hospital Boston, Boston, Massachusetts. ·
9/29/05
"Research Using
Human ES Cells: A Tale of Two Cities…", Lecture and Panel, Emerging
Technologies Conference, Massachusetts Institute of Technology, "Stem Cells
and the State" Charles C. Mann, Moderator. Cambridge, Massachusetts. ·
9/21/05
"Personalized Medicine: Stem Cells and Genetics", Invited Panelist,
Stanford University, Department of Genetics Annual Retreat, Julie Baker, Ph.D.,
Moderator. Monterey, California. ·
9/21/05
"Embryonic Stem Cells: Working Towards a More Complete Understanding of Human
Developmental Genetics and Congenital Diseases", Stanford University, Department
of Genetics Annual Retreat. ·
9/01/05
"Braving
Medicine's Frontier", Magazine Interview, MIT Technology Review, September
2005, Charles C. Mann, author. ·
8/04/05
"Making Sense of Stem Cells", Film Interview, International Society
for Stem Cell Research, Susan J. Garfinkel, Ph.D., Public Education Committee
Chair, organizer. (go
to site online) ·
7/06/05
"Embryonic Stem Cell Research: a Political and Scientific Time-Line"
Harvard Stem Cell Institute Summer Seminar Series, Harvard University, Cambridge,
Massachusetts. ·
6/21/05
"Stem Cell Funds Launch a Scientific Gold Rush", Newspaper Interview,
Contra Costa Times (Walnut Creek, CA), Betsy Mason, author. ·
5/18/05
“Conducting Stem Cell Research”, Newspaper Interview, Taunton Gazette
(Taunton, MA), Joanna James, author. ·
5/18/05
"Stem Cell Research: Past, Present, and Future", Morton Hospital and
Medical Center Graduate Medical Education Seminar, Taunton, Massachusetts. ·
5/06/05
"The State of Stem Cells", Live Radio Panel, on The Exchange, New Hampshire
Public Radio, Two person panel with Eric Cohen, Director of the Biotechnology
& American Democracy Program at the Ethics and Public Policy Center, Editor
of The New Atlantis and Consultant to the President’s Council on Bioethics,
Laura Knoy, host. (go
to site online) ·
4/21/05
Town Hall Meeting on Stem Cell Research, Lecture and Panel, Jamaica Plain, Massachusetts.
State Representative Jeffrey Sanchez, moderator. ·
4/19/05
"The Cloning Process", Photo Essay, NOVA Science NOW, Accompanying material
for segment on Stem Cells. (go
to site online) ·
4/14/05
“Clear Science, Uncertain Future?”, Essay, Bridges Magazine, Office
of Science and Technology, Embassy of Austria, Washington, D.C., (go
to site online) ·
3/31/05
“Inside a Stem Cell Laboratory”, Lecture and Panel, Stanford University
Club of New England and Gadsby Hannah's Technology and Emerging Growth Group (Gadsby
Hannah LLP), Boston, MA. ·
3/17/05
New England Cable News Network (NECN), Television Interview, regarding science
and policy issues in embryonic stem cell research. ·
3/17/05
MassCURE, News Conference, Commonwealth of Massachusetts State House. (go
to site online) ·
3/15/05
"Stem Cell Research: Policy and Personal Perspectives", Lecture, Frontiers
of Health Science on Friday, Museum of Science, Boston, Massachusetts. (go
to site online) ·
3/07/05
“The Global State of Stem Cells & Cloning in Science, Ethics & Law”,
Lecture, Panel, Newspaper Interviews, Television Interview, Pontifical University
Regina Apostolorum, Rome, Italy. Eric Cohen, Senior Research Consultant, President’s
Council on Bioethics, Moderator. (go
to site online) ·
3/03/05
“Being a Young Investigator in a Contentious Field” News Conference
“The Politics and Promise of Stem Cell Research”, Howard Hughes Medical
Institute (HHMI) in collaboration with the Center for Strategic and International
Studies (CSIS), Washington, D.C., Leonard Zon, organizer. (go
to site online) ·
2/15/05
“Stem Cell Research: A View from the Front Lines.” Lecture and Panel,
National Association of Science Writers at the AAAS Annual Meeting, (go
to site online) ·
2/09/05
“Stem Cell Research at Harvard.” Lecture and Panel, Boston Chapter of
Hadassah and Mishkan Tefilah Synagogue. ·
2/02/05
“A New Twist for Embryonic Stem Cells in the Heart”. Lay Review, International
Society for Stem Cell Research (ISSCR) website. (go
to site online) ·
1/24/05
“Human Embryonic Stem Cells: Genetic Modification and Directed Differentiation”,
Churchill College, Møller Centre, University of Cambridge, England. ·
1/06/05
“A Personal View of Stem Cell Research”, Lecture and Panel, Boston Athenaeum,
Ann Parson, moderator. (go
to site online) ·
12/05/04
“Stem Cell Research Deserves Respect, Not Scorn”, Essay, Salt Lake Tribune,
Utah Voices, Salt Lake City, Utah. (go
to copy of article) ·
12/05/04
“When Stem Cell Research Gets Personal”, Newsmagazine Interview, Boston
Globe Sunday Magazine, Ann Parson, writer. ·
10/20/04
"Human Embryonic Stem Cell Research: One Perspective" Lecture and Discussion,
Brown Bag Bioethics Discussion, Division of Hematology/Oncology, Children's Hospital
Boston. ·
7/15/04
“The Controversies in Stem Cell Research”, Live Radio Interview, Market
Wrap, WBIX Radio Boston, Mark Mills, host. ·
6/13/04
"Stem Cell Research: The Struggle Between Politics & Medicine",
Lecture and Discussion, Jewish Alliance for Law and Social Action, Young Social
Activist Dinner and Lecture, with Cynthia Stone Creem, State Senator for Massachusetts,
Temple Ohabei Shalom, Brookline, MA. ·
6/09/04
Research Advocacy/Lobbying, Joint Steering Committee for Public Policy (ASCB),
Capitol Hill Day, Washington, D.C. ·
4/20/04
“Using Embryonic Stem Cells to Understand Human Development and Disease”,
Department of Biology, Utah State University, Logan, Utah. ·
4/20/04
“Biological Engineering Opportunities at MIT”, Biotechnology Center,
Utah State University, Logan, Utah. ·
4/16/04
“Stem Cell Research: Origins, State of the Art, and Future Directions”,
Lecture, MIT Senior Congressional Staff Seminar: “Social and Policy Implications
of Advancing Health Science and Technology”, Stephen Ansolabehere, Ph.D.
and Robert Weinberg, Ph.D., organizers. Jonathan Gruber, Ph.D., moderator. ·
1/29/04
“Stem Cell Debate Reignited”, Radio Interview, WBUR Radio Boston, Rachel
Gotbaum, author. (go
to site online) ·
11/06/03
“Stem Cell Research: Science and Politics”, Lecture and Panel, Whitehead
Institute Board of Associates Annual Meeting, Harvey Lodish, Ph.D., moderator. ·
10/23/03
“With Respect and Conscience”, Magazine Interview, Paradigm magazine,
Whitehead Institute for Biomedical Research, Melissa Withers, author. (go
to site online) ·
6/18/03
“Stem Cell Research”, Testimony, State of Utah Legislature, Democrat
Representatives’ Caucus. ·
5/01/03
“Stem Cell Research”, Testimony, Commonwealth of Massachusetts State
House, joint legislative session on stem cell research. ·
10/02/02
“Genetic Engineering of Human and Murine Embryonic Stem Cells”, Biotechnology
Process Engineering Center, Massachusetts Institute of Technology, Cambridge,
Massachusetts. ·
4/08/02
“Hematopoiesis and Human Embryonic Stem Cells”, Mammalian Development
Seminars, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts. ·
3/15/02
“Clonal Selection: The Leukemic Process in Fanconi Anemia”, Thesis Defense,
Department of Molecular and Medical Genetics, Oregon Health Sciences University,
Portland, Oregon. ·
6/15/01
“Clonal Evolution in Fanconi Anemia”, Whitehead Institute for Biomedical
Research, Cambridge, Massachusetts. ·
5/28/01
“Genetic Determinants in Secondary MDS/AML and Fanconi Anemia”, Terry
Fox Cancer Research Laboratories, Vancouver, B.C. ·
3/16/00
“Genes Involved in Copper Metabolism”, Grand Rounds, Molecular and Medical
Genetics, Oregon Health Sciences University, Portland, Oregon. ·
1/27/99
“Genetic Analysis of Secondary Myelodysplastic Syndrome”, Departmental
Seminar, Molecular and Medical Genetics, Oregon Health Sciences University, Portland,
Oregon. ·
1997
“Spongiform Encephalopathies, Prions, and Genetics”, Department of Molecular
and Medical Genetics Student Seminar, Oregon Health Sciences University, Portland,
Oregon. ·
1994
“The Genetics of Neurofibromatosis”, Neuroscience Graduate Program Student
Seminar, University of Pennsylvania, Philadelphia, Pennsylvania. ·
1992
“Gene Mapping in Neuromuscular Disease”, Eccles Institute Public Outreach,
Department of Pediatrics, Division of Clinical Genetics, University of Utah, Salt
Lake City, Utah.
Patents:
·
Chance PF, Alderson MK, Odelberg SJ, and Lensch MW.
Deletion in chromosome 17p11.2-12 which causes the disorder hereditary neuropathy
with liability to pressure palsies. United States Patent number 5,645,993 issued
July 8, 1997. (go
to patent)
